Franciszkańska Street was the longest thoroughfare in the Litzmannstadt Ghetto. For many Jews from Western Europe it became the last address before deportation to death camps. At the beginning and the end of the street German guardhouses were located. Elegant townhouses in its southern part, near the Biedermann palace, housed important institutions. At number 27, in parish buildings of the Mariavite church (turned into warehouse) a Jewish police station was located. The Summary Court and the Commission of Deportations were located, which, at the beginning of 1942, compiled a list of the ghetto inhabitants to be sent to the extermination camp at Chełmno on the Ner. At 29 Franciszkańska St. a primary school was established, operating until the autumn of 1941, and since May 1942 – Tailor Division. In autumn 1941, after nearly 20 thousand Jews from Western Europe had been deported to the ghetto, many of them were located in housing collectives along Franciszkańska Street. At number 13, there was a collective of persons deported from Frankfurt am Main; at number 21 lived the Jews brought from Prague on transports II and III. At 27 Franciszkańska St., there was the Berlin IV collective, in the house at number 29 - Prague IV collective. On the opposite side of the street, in the house at number 30, an orthodox synagogue was located, as well as a communal kitchen and Clothing Department. At 31 Franciszkańska St., in the former "Bajka" cinema, from October 17 until November 27, 1941 the seat of the Hamburg collective was located. After it had been moved to 25 Młynarska St., the building was turned into a reformed house of worship, meant for the Jews of Western Europe. The last collective at Franciszkańska St. was located at number 37 – Jews brought on the Prague III transport lived there.

It was there, at Franciszkańska St., where the sisters of Franz Kafka lived, brought in the transports from Prague - Gabriele Hermannova (13/15 Franciszkańska St.) and Valerie Pollakova (29 Franciszkańska St.).